GLP-1 titration & side-effect management
Also known as:
Semaglutide and tirzepatide prescribing
Start low, go slow, and anticipate GI effects, gallbladder risk and lean-mass loss.
Written and reviewed by Farhan Tahir, MD · Last reviewed
VIDEO LESSON
Titration
• Follow labeled 4-week dose steps; slow down or pause escalation for GI symptoms
• Not every patient needs the maximum dose
• Counsel on smaller meals, hydration and protein before starting
Safety
• GI effects are the most common; most are mild to moderate and transient
• Watch for gallbladder disease and pancreatitis symptoms
• Contraindicated with personal or family history of medullary thyroid carcinoma or MEN2
• Review insulin and sulfonylurea doses to avoid hypoglycemia
• Stop before conception as labeled; discuss contraception
• Inform anesthesia teams before procedures because of delayed gastric emptying
Monitoring
Weight, blood pressure, glucose, lipids and symptoms at each step; strength or lean mass where available.
Key studies and references
Educational content only, written and reviewed by Farhan Tahir, MD. It does not replace individual medical advice. For sudden chest pain, trouble breathing or stroke symptoms, call 911.
AT A GLANCE
Section
Prescribing & monitoring
Also known as
Semaglutide and tirzepatide prescribing
Reviewed by
Farhan Tahir, MD
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