Obesity-related heart failure (HFpEF)
Also known as:
Heart failure with preserved ejection fraction
A stiff heart driven by obesity and inflammation. Incretin medicines and SGLT2 inhibitors now help.
Written and reviewed by Farhan Tahir, MD · Last reviewed
VIDEO LESSON
What it is
In HFpEF the heart pumps normally but fills poorly because it is stiff. Obesity is a major driver, through excess fat around the heart, inflammation, high blood volume and pressure.
Symptoms
• Breathlessness with exertion
• Fatigue and reduced exercise capacity
• Leg swelling
Treatment
SGLT2 inhibitors reduce hospitalization for heart failure in HFpEF. In STEP-HFpEF, semaglutide improved symptoms, physical limitations and exercise capacity in people with obesity-related HFpEF. In SUMMIT, tirzepatide reduced the combined risk of cardiovascular death or worsening heart failure. Diuretics relieve fluid overload.
Key studies and references
Trusted resources
Educational content only, written and reviewed by Farhan Tahir, MD. It does not replace individual medical advice. For sudden chest pain, trouble breathing or stroke symptoms, call 911.
AT A GLANCE
Category
Heart & related conditions
Also known as
Heart failure with preserved ejection fraction
Reviewed by
Farhan Tahir, MD
Questions about your own care?
Dr. Tahir’s team offers consults through Youthful Medicine.
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